Insulin is an important hormone for the metabolism in the human body. It serves mainly to inject glucose (glucose) from the blood into the cells. There the sugar molecules are needed for energy production.
Carbohydrates from food reach the small intestine via the stomach. There, they are split into glucose and enter the bloodstream via the intestinal wall. It is called the key, which opens the cells for the sugar molecules. In addition, Insulin is attached to the insulin receptors of the cells.
Insulin as a key function
Insulin feeds sugars mainly into the cells of the muscles, liver, kidneys and adipose tissue, but not into the brain. The brain cells can absorb glucose independently of the insulin.
Besides this key function, it has other tasks in the body. It affects the feeling of appetite in the brain. In addition, insulin prevents the breakdown of adipose tissue, the so-called lipolysis. In the case of complete insulin deficiency, adipose tissue is no longer kept in the depots, and free fatty acids float the organism, which can lead to serious metabolic disorders.
An Insulin deficiency in the body leads to sugar diabetes mellitus, one of the most common metabolic disorders in humans. In school medicine, insulin is prescribed for type I diabetes mellitus, also called “Insulin-sensitive diabetes”. In this disease, the pancreas of the person concerned is incapable of producing insulin independently, which necessitates exogenous administration, ie, insulin injections. If this disease remains untreated, severe hypersensitivity reactions are the result.
Insulin in bodybuilding
The reason why Insulin is used in bodybuilding is almost exclusively the growth hormone. Insulin itself is not a hormone that is administered alone resulting in miraculous muscle growth. Rather, insulin is an activator which significantly increases the muscle-building effect of anabolic steroids (testosterone enanthate, testosterone cypionate, testosterone propionate, etc.), IGF-1 and, in particular, growth hormone. Indirectly, it can also help develop muscles by relaxing and dilating the blood vessels, thus increasing blood flow into the muscles. This results in more nutrients, such as glucose and amino acids, to the muscles. Therefore, bodybuilders usually take carbohydrates at competitions. The peak of insulin not only brings these carbohydrates directly into the muscles, but also stimulates the vascularization (also known as pumping effect known process).
Insulin “works” mainly in combination with HGH and is therefore usually used together with this. In the digestive sport already small (one can say, physiological) doses are sufficient to accelerate the muscular regeneration after an intensive load!
The scientific literature contains a large number of studies that precisely document why the combined administration of insulin and the growth hormone produces a far stronger effect than when the respective hormones are administered separately. Both growth hormone and Insulin increase the protein content in the muscle, but the largest increase in protein in the muscle tissue can only be measured with a combined application.
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Insulin Scientific Information Insulin / HGH
As we know, a majority of the growth hormone drug reaches the liver after an injection. The task of the liver cells is now to begin the production of IGF-1. However, in addition to testosterone and thyroid hormones, insulin is also required in this case in a sufficiently high quantity. However, this is hap- pening in many growth hormone users, since a healthy adult consumes only about 50 I.U. 2mg, insulin. This available amount of insulin is unfortunately not enough to guarantee maximum IGF-1 production after growth hormone injection into the liver. One can not simply increase the growth hormone level in the body by growth hormone injections many times, while hoping for the highest possible IGF-1 formation if not all the other necessary IGF-1 simulators, testosterone, thyroid hormone, and in particular insulin, are simultaneously raised.
Insulin and insulin production / HGH
The body is aware of this problem, but it reacts initially to growth hormones with an increased insulin production. The growth hormone has the property of causing the pancreas to increase the release of insulin. The insulin level in the blood increases and the liver can now start the IGF-1 production with the additional insulin. The problem, however, is that a sustained administration of the growth hormone leads to a damage of the beta cells into the Langerhansian insulin and the insulin production, which is initially running on high trances, If the growth hormone application is long enough, especially at higher doses, the body’s insulin production can drop to a worrisome level. In addition to serious health problems, such as the possible emergence of a high blood glucose level and resulting diabetes mellitus, this also has a negative impact on IGF-1 production in the liver. Moreover, scientific studies have clearly demonstrated that an insulin deficit leads to a loss of growth hormone receptors in the liver, which means that part of the injected growth hormone can not be used by the liver with high likelihood.
Insulin Growth Hormone Cure / HGH Cure
If, on the other hand, a sufficiently high level of insulin is provided in the course of a growth hormone therapy with the aid of insulin injections, body builders will end up with a series of hits. The most important thing, of course, is that the liver is able to produce a maximum amount of IGF-1. The same is also true for the muscle cells, which can also locally form IGF-1 from testosterone, thyroid hormones (levothyroxine T4, liothyronine T3), growth hormone and insulin. Measurements of the IGF-1 level in the blood showed, in scientific studies, that the growth hormone-insulin combination is associated with significantly higher values than when administered separately. Furthermore, insulin improves the anabolic effect of the body-produced IGF-1 by positively regulating the synthesis and serum concentration of IGF-1 binding proteins. Insulin: the formation of the important IGF-1 / IGFBP-3 complex in the blood. IGFBP-3 is a binding protein that binds IGF-1 in blood to itself and thus protects against degradation. Thus, a simple reference chain can be constructed: insulin stimulates the IGF-1 / IGFBP-3 complex, IGFBP-3 prolongs the life expectancy of IGF-1 in the blood, which in turn increases the efficacy of IGF-1. Finally, the insulin regulates the growth hormone receptors upwards in the liver, thus enabling the processing of high growth hormone dosages. Here, too, scientific studies have shown that the excretion rates of growth hormone in the urine, with simultaneous insulin administration, are much lower than when administered alone.
Furthermore, there is a synergistic effect on protein metabolism between growth hormone and insulin. Both hormones promote the penetration of amino acids into the muscle cells by increasing cell membrane permeability, ie the permeability of the cell wall. In the muscle cell itself, both insulin and growth hormone stimulate protein synthesis, i.e. The muscle experiences a thickness growth and grows in the width.
Insulin vs. Growth hormone cure / in comparison
If the effect of insulin and the growth hormone is compared even more closely, another imposing similarity is apparent. Both hormones promote the protection of protein. Insulin does so at the expense of glucose, the growth hormone at the expense of fatty acids. In bodybuilding jargon it is an anti-catabolic effect. Insulin protects the athlete in stressful situations (e.g., over training) or in the case of a lack of nutrition (e.g., competition diets) against loss of muscle tissue. The reason is that insulin, as well as the growth hormone, inhibits a process called gluconeogenesis. Gluconeogenesis is an energy recovery process that takes place in the liver and which consumes protein as a fuel. A horrible adjustment for every bodybuilder. Muscle tissue is degraded and metabolised in the liver. Here, the hormone provides insulin remedy, it prevents gluconeogenesis and the protein reserves in the muscles remain intact. Since insulin (by providing glucose) and the growth hormone (by the provision of fatty acids) inhibit gluconeogenesis in different ways, its effect and simultaneous administration complement a significantly greater protein-protecting effect than when only one of the two hormones is used .
Insulin – Growth hormones – Clenbuterol – Thyroid hormones:
However, many bodybuilders are extremely skeptical about the use of insulin. However, this rejection is usually not based on the fear of possible damaging side effects. Hardcore bodybuilders who take several steroids, the growth hormone, thyroid hormone (levothyroxine T4, liothyronine T3), clenbuterol, diuretics, etc. are hardly afraid of insulin. Rather, the knowledge about the antilipolytic properties of the insulin causes bodybuilders to leave the fingers of this hormone. Insulin enjoys the dubious reputation of challenging fat intake. An absolutely correct assessment, it is known that insulin increases the uptake of glucose into the fetal cell and also inhibits the release of free fatty acids from the fetal cell.
Insulin Efficacy / Application / Dosage:
First of all, the athlete felt insulin is currently administered only by injections (tests for insulin sprays for inhalation are already running). The best route of administration is subcutaneous injections. The insulin is injected directly under the skin of the abdominal wall. Special insuline needles with a diameter of 0.45 mm and a length of 12 mm are used. One can choose from different types of insulin, because there are both insulin preparations of animal origin, where the insulin is obtained from bovine and porcine pancreas, as well as insulin, which is produced by recombinant DNA technology, which is also called “insulin human” in specialist jargon.
In order to exclude the possibility of antibody formation, bodybuilders use exclusively genetically engineered insulin. In addition, the selection of the appropriate insulin preparation makes a distinction between three different periods of action:
- Short acting insulin with a maximum duration of 8 hours.
- Intermediate effective insulin with a maximum duration of 24 hours.
- Long-acting insulin with a maximum duration of 36 hours.
For example, if you inject a short-acting insulin with an 8-hour duration, you can not expect the effect to be constant from the first to the last minute.
For this reason, all the insulin preparations are divided into three phases, the so-called effect profile. Each insulin consumer must be absolutely familiar with the efficacy profile of his preparation, otherwise serious errors can hardly be avoided.
- Time of start of action
- Period of maximum effect
- End of effect
Insulin application Muscle build-up:
The top priority for bodybuilders who inject insulin is that its effect must be controllable. In the case of preparations with a long period of action, this is much more difficult than with the short-acting variants. Thus, intermediates and long-acting insulins remain active in the body for 24 and 36 hours, respectively. The risk of these two insulin variants is that their blood glucose lowering effect also exists at night, when you sleep. In contrast to the waking attendance, however, the symptoms of hypoglycemia during sleep can not be noticed. But also in the day, the omission of a meal, the temporal shifting of a meal or a sudden change in the food selection, e.g. More protein and less carbohydrates, lead to a significant blood glucose drop with the classic symptoms of hypoglycemia.
Reasonable athletes therefore forego the application of a long-acting as well as intermediate insulin. Surely a long-acting insulin preparation may be most convenient to handle, after all, only one injection per day is required, but the risk of losing control over the 24-36 hours of persistent blood-sucking effect is too great. Furthermore, it should be noted that intermediate and long-acting insulin does not correspond to the physiological conditions of the body since they are present in the organism as an active but not required insulin for longer periods of time, irrespective of the need. It is therefore presumed that there are connections between these insulin variants and the increased occurrence of arteriosclerotic changes.
Insulin application Dosage:
Thus the best choice is to use a short-acting insulin. Its effect can be most easily controlled. On the one hand the effect begins already 30 minutes after the injection and on the other hand the effect holds at most 5-8 hours. With the knowledge that the main effect of most short-acting insulin occurs in the time of 2-3 hours after the onset of action, food intake is easier to plan. The disadvantage is the shorter injection intervals, i. The athlete must use the syringe more frequently. As a rule, 10-20 I.U. insulin. The first injection of 10-20 I.E. insulin takes place early in the morning, immediately before breakfast, immediately after breakfast, the athlete then applies the growth hormone. The breakfast should supply 800-1200 calories and 150-200g of carbohydrates. Two thirds of the Konenydrate should be of a complex nature, e.g. Oatmeal, while one-third is derived from simple carbohydrates, such as bananas, dried fruits, or apple juice. The second injection of again 10-20 I.E. Insulin follows directly after the training. Now it is only simple, fast absorbable carbohydrates to consume, depending on the height of the body weight of the individual 100-200g. An excellent carbohydrate donor is the already mentioned apple sauce
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